Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion
نویسندگان
چکیده
منابع مشابه
Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion.
Gait disturbances similar to those of human Parkinson's disease (PD) can be observed in animals after administration of neurotoxin 6-hydroxydopamine (6-OHDA) to induce unilateral nigrostriatal dopamine depletion. However, the relationship between gait disturbances and dopamine depletion following 6-OHDA infusion has not been determined. The present study investigated the longitudinal changes of...
متن کاملExercise-induced neuroprotection in a hemiparkinsonian 6-hydroxydopamine rat model
.............................................................................................................................................. iii ACKNOWLEDGEMENTS ........................................................................................................................... v LIST OF TABLES ...............................................................................................
متن کاملTime-course behavioral features are correlated with Parkinson's disease-associated pathology in a 6-hydroxydopamine hemiparkinsonian rat model
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. For decades, the unilateral 6‑hydroxydopamine (6‑OHDA) rat model has been employed to investigate the pathogenesis and therapy of PD. However, the behavior and associated pathological features of the model long term have not previously been described dynamically. In the present study, the unilateral model was establi...
متن کاملAltered nucleolar morphology in substantia nigra dopamine neurons following 6-hydroxydopamine lesion in rats.
The nucleolus, the site of ribosomal ribonucleic acid (rRNA) transcription and assembly, is an important player in the cellular response to stress. Altered nucleolar function and morphology, including decreased nucleolar volume, has been observed in Parkinson's disease; thus the nucleolus represents a potential indicator of neurodegeneration in the disease. This study determined the effects of ...
متن کاملMethamphetamine-Induced Dopamine-Independent Alterations in Striatal Gene Expression in the 6-Hydroxydopamine Hemiparkinsonian Rats
Unilateral injections of 6-hydroxydopamine into the medial forebrain bundle are used extensively as a model of Parkinson's disease. The present experiments sought to identify genes that were affected in the dopamine (DA)-denervated striatum after 6-hydroxydopamine-induced destruction of the nigrostriatal dopaminergic pathway in the rat. We also examined whether a single injection of methampheta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Behavioural Brain Research
سال: 2011
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2011.03.031